AI for Science: Gabriele Corso "Boltz: Towards Accurate Biomolecular Modeling and Design"

Abstract

Accurately modeling biomolecular interactions is a central challenge in modern biology. Recent advances have substantially improved our ability to predict biomolecular complex structures, understand the strength of interactions and design novel binders. I will present some of our open-source (Boltz-1, Boltz-2 and BoltzGen) and proprietary work pushing the frontier across all of these tasks and how these come together in accurate pipelines for structure-based biologics and small-molecule design.

Bio

Gabriele Corso is the CEO and co-founder of Boltz PBC, a company aiming to advance biomolecular modeling and making it accessible to scientists. Gabriele received his PhD from MIT CSAIL where his research focused on developing novel ML frameworks to tackle challenging problems in drug discovery and he led the development of popular models in the space including DiffDock, Boltz-1 and Boltz-2.